Goals from Henrikh Mkhitaryan, who made a mockery of his two-month exile from the starting lineup with a superb individual effort, and Zlatan Ibrahimovic secured an easy win that banished memories of their earlier group stage struggles.
The reigning champions have won 53 and drawn 11 of those 64 games, scoring 169 goals and conceding 42 for a total of 170 points.
Bukayo Saka scored either side of halftime as Arsenal crushed second-bottom Burnley 5-0.
Manchester United and Chelsea secured places in the Champions League with wins on the final day of the Premier League season while Watford and Bournemouth were relegated along with bottom club Norwich City.
Liverpool stuttered into the quarter-finals of the Champions League with a 2-1 aggregate win over Inter Milan after suffering a 1-0 loss to the Italian side, who were reduced to 10 men, at Anfield on Tuesday.
Photos from the English Premier League matches played on Saturday
Liverpool reached the Champions League semi-finals for the first time in 10 years as Mohamed Salah and Roberto Firmino struck decisive blows to secure a 2-1 win over Manchester City on Tuesday that completed a 5-1 aggregate victory.
Hazard extra-time goal sends 10-man Real Madrid through to Copa del Rey final.
Images from the Nations League football matches played on Thursday.
Images from the EPL matches played on Saturday
Premier League champions Liverpool maintained their 100 per cent start to the season with a 3-1 win against Arsenal at Anfield on Monday leaving them level on nine points with pacesetters Everton and Leicester City.
A summary of Saturday's action in the English Premier League.
Manchester United's woes deepened as stunning goals by Moussa Sow and Jeremain Lens gave Fenerbahce a 2-1 Europa League win on Thursday that left Jose Mourinho's side facing a battle to reach the knockout stages.
Round-up of World Cup qualifiers played on Friday
Barcelona coach Ronald Koeman has defended centre-back Gerard Pique's right to make comments about referees favouring Real Madrid.
IMAGES from the English Premier League matches played on Sunday
Images from the English Premier League matches played on Saturday night.
Chelsea kept alive their remote Premier League title chances with a 2-0 win over London rivals Tottenham Hotspur on Sunday, set on their way by an exquisite strike from Hakim Ziyech which was quickly followed up by a Thiago Silva header.
On a day of frenetic spending that took the Premier League total to a record far above one billion pounds ($1.29 billion), Antonio Conte's side also missed out on two of their other targets - Alex Oxlade-Chamberlain and Fernando Llorente.
Paris St Germain revived their Champions League campaign with a 2-1 win over Liverpool in Group C on Wednesday, leaving the English club's hopes of reaching the last 16 hanging in the balance.
Manchester City needed a second-half penalty from striker Erling Haaland to break the resistance of a dogged Crystal Palace.
IMAGES from the EPL matches played on Wednesday.
Arsenal suffered another painful Premier League defeat as Swansea City capitalised on some glaring errors to win 3-1 on Tuesday, boosting their survival hopes and denting the visitors' top four chances.
Images from the World Cup qualifying matches played on Monday.
IMAGES from the English Premier League match played between Arsenal and Chelsea at Emirates Stadium in London on Sunday.
Images from the English Premier League matches played on Saturday.
The Netherlands failed to reach the European Championship for the first time since 1984 as they lost 3-2 at home to the 10-man Czech Republic in their final qualifier on Tuesday to miss out on Euro 2016.
Images from the Champions League matches played on Tuesday
Real Madrid moved into the semi-finals of the Champions League after their makeshift defence held on for 0-0 second-leg draw with Liverpool at Anfield on Wednesday to complete a 3-1 aggregate win.
News of all that's transpired on and off the football field
IMAGES from EPL matches played on Sunday.
The following is a look back on key moments in the thrilling Premier League title race, won by Manchester City on Sunday:
In a gripping title race, Liverpool showed they are ready to push Manchester City right until the final seconds of this season with their spirited 3-2 win at Newcastle United.
IMAGES from the English Premier League matches played on Saturday
Tottenham Hotspur and Liverpool raised the spirits with a rip-roaring 2-2 draw in a pre-Christmas Premier League classic on Sunday after a weekend marred by COVID-19 related postponements.
Messi, whose deal expires in 2021, had called his side "weak" and "inconsistent" after they lost the league title to Real Madrid.
He increasingly looks like a manager unable to cope with the modern tactical realities of football. His display of a fear of failure has been appalling to watch. But Mourinho getting the sack at this juncture will hardly solve the problem, says Dhruv Munjal.
Barcelona were held to a frustrating 0-0 draw at Olympique Lyonnais in their Champions League last-16 first leg on Tuesday as both sides remained unbeaten in this season's competition.
Luka Modric pulled one back for Zinedine Zidane's shellshocked side with a brilliant strike from distance early in the second half before substitute Vinicius Jr reduced the deficit to one goal.
Images from Saturday's action in the English Premier League.
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